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Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
Authors:Sun-Seog Kweon  Young-Hoon Lee  Seul-Ki Jeong  Hae-Sung Nam  Kyeong-Soo Park  Seong-Woo Choi  Bok-Hee Kim  Hee Nam Kim  Jin-Su Choi  Min-Ho Shin
Abstract:The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea.

Graphical Abstract

Keywords:Homocysteine   Folic Acid   Reference Intervals   Aged Population
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