New methods to control neuroblastoma growth |
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Authors: | Paul Dent |
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Institution: | Department of Biochemistry and Molecular Biology; Massey Cancer Center; Virginia Commonwealth University; Richmond, VA USA |
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Abstract: | Downstream of growth factor receptors, signaling by the phosphoinositide 3 kinase (PI3K) pathway is known to play an important role in the growth and survival of many tumor types. The PI3K pathway simplistically comprises PI3K itself, followed by PDK-1, then AKT and finally glycogen synthase kinase 3 (GSK3).1 PI3K/AKT signaling promotes increased GSK3 phosphorylation, that is associated with reduced GSK3 activity. There are two isoforms of GSK3, GSK3α and GSK3β, which have a high degree of sequence homology.2 GSK3 plays a role not only in the regulation of glycogen synthase activity but in the expression of multiple other proteins that play a role in cancer biology, including cyclins and anti-apoptotic proteins.3,4 |
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Keywords: | AR-A014418 GSK3 apoptosis neuroblastoma |
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