左氧氟沙星及力克菲蒺治疗耐多药肺结核病的疗效观察

目的观察含左氧氟沙星和力克菲蒺的化疗方案在治疗耐多药肺结核病的疗效。方法将98例耐多药肺结核分为治疗组50例和对照组48例,治疗组以左氧氟沙星和力克菲蒺为主,联合丁胺卡那霉素、利福喷丁、丙硫异烟胺;对照组用丁胺卡那霉素、利福喷丁、丙硫异烟胺、吡嗪酰胺及乙胺丁醇,疗程均为21个月。结果疗程结束后,治疗组痰菌阴转率、空洞闭合率及病灶吸收好转率分别为82%、77.5%及84%,对照组则分别为56.3%、54.3%及52.1%,两组比较差异显著(分别为P<0.01,P<0.05及P<0.005);两组的不良反应分别为30%及27.1%,差异无显著性(P>0.05)。结论含左氧氟沙星及力克菲蒺的方案治疗耐多药肺结核安全有效,值得推广应用。

The clinical observation on the efficacy of the short-term with levofloxacin and pasiniazide in the treatment of multi-drug resistant pulmonary tuberculosis

Objective To study and observe the clinical efficacy of a combined therapy of levofloxacin(LVFX),pasiniazide(Pa) and other antituberculosis drugs in the treatment of multi-drug resistant pulmonary tuberculosis(MDR-TB).Methods 98 patients with MDR-TB were assigned to a study group(50 cases),treated with LVFX,Pa,amikacin(AK),rafapentine(RFT) and prothionadam(1321TH),and a control group(48 cases),treated with AK,RFT,1321TH,ethambutol(EMB) and pyrazinamide(PZA).The course of treatment was 21 months.Results When the course was completed,the sputum negative conversion rate,the closure rate of the lung cavities and the radiographic resolution rate in the study group were 82%,77.5% and 84%,respectively,which were higher than that in the controls(56.3%,54.3% and 52.1% respectively): P<0.01,0.05 and 0.005 respectively.And no significant difference was found in side-effects between the two groups(30% in the study group,and 27.1% in the control group): P>0.05.Conclusion The scheme including levofloxacin and pasiniazide was effective and safe for the patients with MDR-TB.