Differentiation of bone marrow stromal stem cells into cardiomyocyte-like cells in different mammalian species |
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| Authors: | Shumakov V I Onishchenko N A Krasheninnikov M E Zaidenov V A Potapov I V Bashkina L V Bersenev A V |
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| Affiliation: | (1) Institute of Transplantology and Artificial Organs, Ministry of Health of Russian Federation, Moscow |
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| Abstract: | We describe the possibility of obtaining cardiomyocyte-like cell cultures from rat, guinea pig, and human bone marrow stromal stem cells. The content of troponin I-positive cells attains 35-45% of the total number of cells in the cultures and persists at this level for up to 4 months under differentiation conditions. Spontaneous contractions of cardiomyocyte-like cells were observed after the formation of cell monolayer under differentiation conditions. |
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| Keywords: | bone marrow stromal stem cells troponin I |
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