Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat |
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| Institution: | 1. Department of Otolaryngology, Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey;2. Department of Otolaryngology, Yıldırım Beyazıt University Medical School, Ankara, Turkey;3. Department of Physical Therapy and Rehabilitation, Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey;4. Department of Otolaryngology, Ministry of Health, Ankara Ulus State Hospital, Ankara, Turkey;6. Department of Otolaryngology, Karabük University Medical School, Karabük, Turkey;1. National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str, 17, Vladivostok, 690041, Russian Federation;2. School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690091, Russian Federation;1. Department of Anatomy, Histology, and Embryology, Heilongjiang University of Chinese Medicine, Harbin, China;2. Department of Pharmacology, Harbin Medical University, Harbin, China;3. Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, China;4. Department of Pharmacology, Da-Qing Campus of Harbin Medical University, Da-Qing, China |
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| Abstract: | Microinjections of γ-aminobutyric acid (GABA) and glycine, into the medial area of the nucleus tractus solitarii (NTS) of the rat, led to an increase in arterial pressure and heart rate. The GABA receptor antagonist bicuculline and the glycine receptor antagonist strychnine decreased both of these cardiovascular parameters whereas the GABA uptake inhibitor nipecotic acid produced hypertension. High K+ stimulation caused a calcium-dependent release of GABA and glycine from tissues in the area of the NTS. Our results suggest that GABA and glycine may modulate the cardiovascular control within the NTS. |
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