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| D-最优混料设计优化寒痹舒凝胶膏剂的基质组成及其体外评价 | |
| 引用本文： | 吴东盼,田雪峰,蔡学军,陈照林,张超,王海洋,马秉智,陆进,吴清. D-最优混料设计优化寒痹舒凝胶膏剂的基质组成及其体外评价[J]. 中草药, 2015, 46(10): 1445-1453 |
| 作者姓名： | 吴东盼 田雪峰 蔡学军 陈照林 张超 王海洋 马秉智 陆进 吴清 |
| 作者单位： | 1. 中日友好医院药学部,北京100029;北京中医药大学中药学院,北京 100102 2. 中日友好医院药学部,北京,100029 3. 北京中医药大学中药学院,北京,100102 |
| 摘 要： | 目的优化寒痹舒凝胶膏剂的基质配方并研究其体外释放和透皮吸收行为。方法采用D-最优混料设计,以含药凝胶膏剂的初黏力、持黏力和胶强度3个指标对基质组成进行优化,确定最优基质配方并进行验证试验;采用改良Franz扩散池法,以蛇床子素为指标进行体外释放和经皮渗透性能的研究。结果寒痹舒凝胶膏剂的基质配方为NP700 6.97g、甘羟铝0.30 g、酒石酸0.25g、甘油35.00 g、PVPK90 3.87g、蒸馏水43.61 g;寒痹舒流浸膏10 g。凝胶膏中蛇床子素24 h体外释放达到(63.30±0.05)%,经皮渗透速率为0.16μg/(cm~2·h),24h累积渗透量为(3.61±0.32)μg/cm~2。结论 D-最优混料设计优化出的寒痹舒凝胶膏剂具有良好的黏附性和成型性。蛇床子素体外释放符合一级方程模型,体外透皮符合零级方程模型。 |
| 关 键 词： | D-最优混料设计 寒痹舒凝胶膏剂 蛇床子素 体外释放 透皮吸收 |
| 收稿时间： | 2015-01-06 |
Matrix formulation of Hanbishu Cataplasma optimized by D-optimal mixture design and research on its in vitro evaluation |
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| WU Dong-pan,TIAN Xue-feng,CAI Xue-jun,CHEN Zhao-lin,ZHANG Chao,WANG Hai-yang,MA Bing-zhi,LU Jin and WU Qing. Matrix formulation of Hanbishu Cataplasma optimized by D-optimal mixture design and research on its in vitro evaluation[J]. Chinese Traditional and Herbal Drugs, 2015, 46(10): 1445-1453 | |
| Authors: | WU Dong-pan TIAN Xue-feng CAI Xue-jun CHEN Zhao-lin ZHANG Chao WANG Hai-yang MA Bing-zhi LU Jin WU Qing |
| Affiliation: | Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China |
| Abstract: | |
| Keywords: | D-optimal mixture design Hanbishu Cataplasma osthole in vitro release transdermal absorption |
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