| ERK信号通路在中药诱导脑缺血耐受中的研究进展 |
| |
| 引用本文： | 张青萍,黄德庆,刘泰.ERK信号通路在中药诱导脑缺血耐受中的研究进展[J].世界科学技术-中医药现代化,2015,17(2):411-415. |
| |
| 作者姓名： | 张青萍 黄德庆 刘泰 |
| |
| 作者单位： | 广西中医药大学第一附属医院 南宁 530023,广西中医药大学第一附属医院 南宁 530024,广西中医药大学第一附属医院 南宁 530025 |
| |
| 基金项目： | 广西壮族自治区科技厅自然资金项目（2011GXNSFA018180）：疏血通脉胶囊预处理对脑缺血大鼠MAPKs通路的影响研究负责人：刘泰；广西壮族自治区科技厅攻关项目（桂科攻11107009-1-11）：缺血性中风新药——疏血通脉胶囊的临床前研究，负责人：刘泰。 |
| |
| 摘 要： | 脑缺血耐受是指机体在遭遇严重的缺血性损伤时的一种内源性脑保护现象。缺血预处理是诱导脑缺血耐受的有效手段,但因其本身的有创性和受伦理限制,难以在临床中实施。研究发现,细胞外信号调节激酶(ERK)信号传导通路在脑缺血耐受的形成机制中有着重要作用,同时中药诱导脑缺血耐受形成有着独到优势。本文就近年来ERK信号通路在脑缺血耐受诱导中的作用以及中药干预作用进行综述。
|
| 关 键 词： | ERK信号通路 脑缺血耐受 中药诱导 综述 |
| 收稿时间： | 6/4/2014 12:00:00 AM |
| 修稿时间： | 2014/9/24 0:00:00 |
Research Progress on ERK Signaling Pathway in Brain Ischemic Tolerance Induced by Traditional Chinese Medicine |
| |
| Zhang Qingping,Huang Deqing and Liu Tai.Research Progress on ERK Signaling Pathway in Brain Ischemic Tolerance Induced by Traditional Chinese Medicine[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2015,17(2):411-415. |
| |
| Authors: | Zhang Qingping Huang Deqing and Liu Tai |
| |
| Institution: | The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530023, China,The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530024, China and The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530025, China |
| |
| Abstract: | Brain ischemic tolerance refers to endogenous brain protective mechanism during severe ischemic injury of the body. Ischemia preconditioning is an effective mean to induce brain ischemic tolerance. However, the invasive and ethical limitation made the application of ischemic preconditioning difficult in the clinical practice. Studies found that extracellular signal regulated kinase (ERK) signaling pathway played an important role in the formation of brain ischemic tolerance. Meanwhile, brain ischemic tolerance induced by traditional Chinese medicine (TCM) had its unique advantages. This article reviewed effects of ERK signaling pathway in the inducing of brain ischemic tolerance and TCM intervention in recent years. |
| |
| Keywords: | ERK signaling pathway brain ischemic tolerance traditional Chinese medicine inducing review |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《世界科学技术-中医药现代化》浏览原始摘要信息 |
| 点击此处可从《世界科学技术-中医药现代化》下载免费的PDF全文 |
