| 正常成年SD大鼠明视闪光视网膜电图特征 |
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| 作者姓名： | Chen H Liu L Lin H Geng Y Zhang M |
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| 基金项目： | 广东省医学科研基金资助项目 |
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| 摘 要： | 目的:探讨正常成年SD大鼠的明视视网膜电图(Electroretinogram,ERG)特征.方法:选取正常9～12周SD大鼠60只,使用罗兰视觉电生理仪记录大鼠右眼的明视闪光ERG.使用SPSS统计分析a波、b波和明视负波反应(Photopic negative response,PhNR)的隐含期和振幅.比较雄性和雌性SD大鼠明视ERG特征.结果:每只SD大鼠均能记录到稳定的a波、b波和PhNR,其中a波的隐含期和PhNR的隐含期及振幅均符合正态分布,而其余指标均不符合正态分布.PhNR的隐含期为124.6±8.5ms,其变异系数最小(0.07).PhNR的振幅为(11.3±4.2)μV,变异系数为0.37.雄性和雌性SD大鼠明视ERG的各反应波之间无显著差异.结论:在正常成年SD大鼠,明视闪光ERG是一项客观评价大鼠明视状态下视网膜功能的手段,PhNR可以作为一项稳定的评价内层视网膜功能的指标.
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| 关 键 词： | 视网膜电图 大鼠 |
The photopic electroretinogram in normal adult sd rat |
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| Chen H,Liu L,Lin H,Geng Y,Zhang M.The photopic electroretinogram in normal adult sd rat[J].Eye Science,2010,25(2):103-106. |
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| Authors: | Chen Hongling Liu Lifang Lin Hongjie Geng Yiqun Zhang Mingzhi |
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| Institution: | Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong,Shantou 515041,China. |
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| Abstract: | PURPOSE:To study the characteristics of photopic flash electroretinogram (ERG) in normal adult SD rats. METHODS:Sixty normal adult SD rats aged 9 to 12 weeks were enrolled in this study. Photopic flash ERG were recorded from these 60 SD rats. The results were statistically analyzed with SPSS software. RESULTS:Stable a, b and PhNR wave could be recorded in each rat. Implicit time of a wave, implicit time and amplitude of PhNR fit normal distribution. Implicit time of PhNR was (124.6±8.5) ms with the smallest coefficient of variation of 0.07. The amplitude of PhNR was (11.3±4.2) μV and coefficient of variation was 0.37. There was no difference in the results between female and male rats. CONCLUSION:Photopic flash ERG is an objective method in evaluating the retinal function in SD rats and PhNR can be used as a sensitive index of inner retinal function. |
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