骨代谢中甲状旁腺激素对相关蛋白和核因子κB受体活化因子的调节

背景：甲状旁腺激素是影响骨代谢功能轴最主要的因素。同时也是调控骨保护素和核因子κB受体活化因子配基表达的重要激素。目的：通过查阅甲状旁腺激素对骨保护素、核因子κB受体活化因子配基调控作用的相关文章,并对其进行综述。方法：以＂甲状旁腺激素,骨保护蛋白,核因子κB受体活化因子＂或＂Parathyroid hormone,osteoprotegerin,receptor activator of nuclear factor κB ligand＂为检索词,由第一作者通过计算机检索CNKI、HighWire数据库中关于＂甲状旁腺激素与骨保护素/核因子κB受体活化因子配基/核因子κB受体活化剂＂的相关的论文报告。选择的文章内容与甲状旁腺激素对信号通路的影响有关、近期发表的文献,按纳入和排除标准对文献进行筛选,共纳入31篇文章。结果与结论：甲状旁腺激素是调节骨代谢最主要的因素,通过增强破骨细胞活动增强而实现的。核因子κB受体活化因子配基是调节骨吸收的关键因子,它通过与核因子κB受体活化剂结合发挥功能。核因子κB受体活化因子配基与核因子κB受体活化剂结合后,启动核因子κB受体活化因子配基信号转导,骨保护素则与核因子κB受体活化因子配基竞争性结合核因子κB受体活化剂,核因子κB受体活化因子配基/骨保护素比值决定破骨细胞分化、成熟及功能。长时间、大强度的运动条件下,机体内甲状旁腺激素的变化是否对于骨保护素、核因子κB受体活化因子配基有影响,进而调节骨代谢的吸收与合成？还有待进一步的研究。

Parathyroid hormone regulation for related protein and receptor activator of nuclear factor-kappa B in bone metabolism

BACKGROUND： Parathyroid hormone is the most important factor to influence the axis of bone metabolism. Meanwhile, parathyroid hormone is the important hormone to regulate osteoprotegerin and receptor activator of nuclear factor-kappa B ligand expression.
OBJECTIVE： To review the articles related to the effect of parathyroid hormone on the regulation of osteoprotegerin and receptor activator of nuclear factor-kappa B ligand.
METHODS： An online search of CNKI and HighWire databases was performed for articles related to “parathyroid hormone, osteoprotegerin, receptor activator of nuclear factor-kappa B and its ligand in bone metabolism”. The keywords of “parathyroid hormone, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand” were used in Chinese and English. Articles related to the effects of parathyroid hormone on the signaling pathways were selected and those published recently or in the authorized journals were of priority. A total of 175 articles were collected in the initial research, and 31 of them were retained according to inclusion and exclusion criteria.
RESULTS AND CONCLUSION： Parathyroid hormone is one of the most important hormones in the regulation of bone metabolism through strengthening osteoclast activity. Receptor activator of nuclear factor-kappa B ligand is the key factor to regulating bone absorption, and functions a role in combination with r eceptor activator of nuclear factor-kappa B to start the receptor activator of nuclear factor-κB factor ligand signal transduction. After that, there is a competition between osteoprotegerin and receptor activator of nuclear factor-kappa B ligand binding with receptor activator of nuclear factor-κB factor. The ratio of receptor activator of nuclear factor-κB factor ligand/osteoprotegerin influences the differentiation, maturation and function of osteoclasts. However, whether the variations of parathyroid hormone in the body during exercise can influence osteoprotegerin and receptor activator of nuclear factor-kappa B ligand to adjust bone absorption and synthesis needs further studies.