纳米羟基磷灰石膜聚氨酯复合材料的体内组织相容性

背景：纳米羟基磷灰石与聚氨酯复合材料在体外实验中具有良好的相容性。目的：验证纳米羟基磷灰石膜聚氨酯复合材料在大鼠体内的组织相容性。方法：将18只SD大鼠随机分为复合材料组、聚氨酯组和对照组，复合材料组和聚氨酯组分别将纳米羟基磷灰石膜聚氨酯复合材料、聚氨酯植入大鼠背部肌肉内，对照组仅作切开缝合，未植入任何材料。结果与结论：①大体观察：术后12周，各组切口与周围皮肤几乎无界限，聚氨酯组及复合材料组囊壁与材料融合较好，对照组皮肤己恢复正常。②组织学观察：术后4，8，12周，聚氨酯组及复合材料组切口周围组织中淋巴细胞数、中性粒细胞数及毛细血管量均高于对照组（P〈0．05），复合材料组切口周围组织中淋巴细胞数、中性粒细胞数及毛细血管量均少于聚氨酯组（P〈0．05）。证实纳米羟基磷灰石膜聚氨酯复合材料具有较好的组织相容性。

In vivo histocompatibility of nano-nydroxyapatite and polyurethane composites

BACKGROUND： Nano-hydroxyapatite/polyurethane has been verified to have an excellent biocompatibility in vitro. OBJECTIVE： To explore the biocompatibility between nano-hydroxyapatite/polyurethane composite and mouse tissues. METHODS： Eighteen Sprague-Dawley rats were randomly divided into nano-hydroxyapatite/polyurethanegroup, polyurethane group and control group. Polyurethane and nano-hydroxyapatite/polyurethane were implanted into the back of rats, respectively, in the polyurethane and nano-hydroxyapatite/polyurethane groups. Nothing was implanted in the control group. RESULTS AND CONCLUSION： （1） Body observation： Incision and surrounding skin almost had no boundaries in all the groups 12 weeks after operation. The capsule wall of polyurethane and nano-hydroxyapatite/polyurethane groups was confluent well with the implant materials, and the skin of the control group recovered. （2） Histology observation： The number of lymphocytes, neutrophils and capillary vessels around the incisions was higher in the polyurethane and nanohydrexyapatite/polyurethane groups than the control group （P 〈 0.05）. In addition, nanohydroxyapatite/polyurethane group has fewer lymphocytes, neutrophils and capillary vessels than the polyurethane groups （P 〈 0.05）. It is verified that nanohydroxyapatite/polyurethane composite has a better histocompatibility.