纤维蛋白胶复合骨形态发生蛋白2塑形Bio-oss修复下颌骨缺损

背景：Bio-oss的颗粒状结构通常应用于洞形缺损的充填性移植，对于三壁以上的缺损修复难以成形。目的：评价Bio-oss以纤维蛋白胶复合骨形态发生蛋白2作为赋形材料后的成骨性能。方法：拔除9条杂种犬双侧下颌第2，4前臼齿及第2臼齿，造成1cmxlcm的骨缺损区，将Bio．OSS＋纤维蛋白胶＋骨形态发生蛋白2、Bio-oss＋纤维蛋白胶及Bio-oss材料分别植入第2，4前臼齿及第2臼齿骨缺损区。结果与结论：各组软组织均一期愈合。Bio-oss复合纤维蛋白胶后，骨粉结合紧密，不易剥离。术后4，8，12周时Bio-oss＋纤维蛋白胶＋骨形态发生蛋白2组新生骨百分率均高于其他两组（P〈0．05）。表明纤维蛋白胶的加入可以解决Bio-oss成形困难的问题，骨形态发生蛋白2的加入可促进成骨效果。

Bio-oss combined with fibrin glue and bone morphogenetic protein-2 to repair mandibular defects

BACKGROUND： Bio-oss granular structure is normally used for hole-shaped defects in the form of filling transplantation, but it is difficult to forming for more than three-wall defects. OBJECTIVE： To evaluate the osteogenic activities of Bio-oss after combination with fibrin glue and bone morphogenetic protein-2 in the repair of canine mandibular defects. METHODS： The second and fourth premolar teeth and the second molar teeth were extracted bilaterally in nine hybrid canines, resulting in 1 cm x 1 cm bone defect. Bio-oss, Bio-oss＋fibrin glue and Bio-oss＋fibrin glue＋bone morphogenetic protein-2 were implanted into bone defects of the second, fourth premolar teeth and the second molar teeth, respectively. RESULTS AND CONCLUSION： Stage ! healing of soft tissues was achieved in all animals. Bio-oss was closely combined with fibrin glue, which was difficult to be separated. The proportion of new bone was higher in the Bio-oss＋fibrin glue＋bone morphogenetic protein-2 group than in the other two groups at 4, 8, and 12 weeks after extraction （P 〈 0.05）. It shows that fibrin glue can solve the difficulty in Bio-oss formation, and Bio-oss combined with bone morphogenetic protein-2 can promote osteogenic activities.