肝癌靶向载体药物的靶向作用与应用分析

背景：肝癌是常见的恶性肿瘤之一，选择有效的治疗药物及治疗方法具有重要的意义。目的：评价载体缓释化疗药物对肝癌的靶向治疗作用及效果。方法：分析临床常用的肝癌化疗药物5-氟尿嘧啶、丝裂霉素以及表阿霉素载体缓释系统对肝脏肿瘤的靶向性特征以及对肿瘤的抑制和杀伤作用。并观察总结海南省农垦总医院肿瘤内科163例中晚期肝癌患者应用化疗药物5-氟尿嘧啶、丝裂霉素、表阿霉素，同时采用导管动脉化疗栓塞辅助治疗的临床效果。结果与结论：5-氟尿嘧啶、丝裂霉素以及表阿霉素载体缓释系统通过不同的作用机制显示出对肝脏肿瘤的靶向性特征，并且对肝脏肿瘤具有较高的抑制和杀伤作用，减少药物用量，降低毒副作用，提高治疗效果。此外，治疗时辅助应用导管动脉化疗栓塞可以延长患者的生存期，提高肝癌的治疗效果。

Targeting effect and application of liver cancer targeting vector drugs

BACKGROUND： Liver cancer is one of the common malignant tumor, and choosing the effective therapy and treatment method has great significance for the treatment of liver cancer. ＇ OBJECTIVE： To evaluate the targeting therapy effect of the carrier sustalned-ralease chemotherapy drugs for the treatment of liver cancer. METHODS： The clinical commonly used liver cancer chemotherapy drugs Included the 5-fluorouracil, mitomycin and epirubicin vector sustained-release system, and the tumor targeting characteristics and suppression and killing effect of these cancer chemotherapy drugs on the tumor were analyzed, A total of 163 patients with advanced liver cancer were selected from Department of Medical Oncology, Hainan Provincial Nong Ken Hospital. The patients were treated with 5-fluorouracil, mltomycin and epirubicin combined with the adjuvant treatment of transcatheter arterial chemoembolization, and then the clinical effect was observed.RESULTS AND CONCLUSION： 5-fluorouracil, mitomycin and epirubicin vector sustained release system show the targeting characteristics to liver tumor through different mechanisms, and have strong inhibiting and killing effect on liver tumors. And the cancer chemotherapy drugs can reduce the drug consumption, decrease the toxicity side effect and thus improve the therapeutic effect. In addition, the combination of transcatheter arterial chemoembolization Can prolong the survival of the patients and improve the therapeutic effect of liver cancer.