The embryology of foregut malformations |
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| Authors: | D Kluth G Steding W Seidl |
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| Affiliation: | 1. Division of Child Health, Menzies School of Health Research, Charles Darwin University, NT, Australia;2. Queensland Lung Transplant Service, The Prince Charles Hospital, QLD, Australia;3. School of Medicine, The University of Queensland, QLD, Australia;4. Department of Respiratory Medicine, Princess Alexandra Hospital, QLD, Australia;5. Telethon Kids Institute, The University of Western Australia, WA, Australia;6. Department of Respiratory Medicine, Queensland Children''s Medical Research Institute, Royal Children''s Hospital, QLD, Australia;1. Foundation of Research and Science Development, Otwock, Poland;2. Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland;3. Department of Transplantation Medicine and Nephrology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland;4. Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland;5. Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland;1. Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA;2. Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA |
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| Abstract: | Developmental disorders in the period of the differentiation of the primitive foregut leads to atresia of the esophagus with tracheoesophageal fistula. Most authors think that this differentiation is caused by lateral foregut folds, which fuse in midline, thus forming the tracheoesophageal septum. In order to gain information about this period of development, we studied the foregut region of chick embryos by scanning electron microscopy (SEM) and light microscopy. In our study no signs of lateral folds or fusing foregut wall components, which were forming a tracheoesophageal septum, were found. Our study suggests that the development of the esophagus and trachea is the result of a simple reduction of the size of the primitive foregut. The consequence for the understanding of the embryology of the foregut malformations is discussed. |
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