A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity |
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| Authors: | Andreas Reif Evelyn Kiive Triin Kurrikoff Marika Paaver Sabine Herterich Kenn Konstabel Tiia Tulviste Klaus-Peter Lesch Jaanus Harro |
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| Institution: | 1.Department of Psychiatry, Psychosomatics and Psychotherapy,University of Würzburg,Würzburg,Germany;2.Department of Psychology, Estonian Centre of Behavioural and Health Sciences,University of Tartu,Tartu,Estonia;3.Central Laboratory, Department of Clinical Biochemistry and Pathobiochemistry,Julius-Maximilians-University Würzburg,Würzburg,Germany;4.National Institute of Health Development,Tallinn,Estonia |
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| Abstract: | Rationale Neuronal nitric oxide synthase (NOS1) knockout results in increased impulsive aggression in mice under adverse housing conditions. In line with this, we have
previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders. |
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