Aetl作用的分子机制及其与免疫损伤性疾病关系的研究进展

T细胞和B细胞介导的免疫应答在A身免疫损伤性疾病的发生与调控中起着至关重要的作用。NF—kappaBActivator1（Actl）是近年来新发现的NF—KB活化因子，参与IL-17、IL-25信号传导的正向调节与CD40L、BAFF信号通路的负向调节，与Thl7细胞和B细胞介导的免疫损伤性疾病以及肿瘤的发生发展有着密切的关系。Actl在IL-17信号和CIMOL—BAFF通路中如此截然相反的作用可能归因于其不同的结构域。Actl这种精巧的调节机制也许有助于机体对病原体的防御与自身耐受平衡的调节。

Progress in researches of molecular mechanism of Actl and its role in autoimmune diseases

T and B cell-mediated immune responses play a critical role in the control and modulation of autoimmune diseases. NF-kappa B Activator 1 （ Actl ） ,also called （ connection to IK B kinase and stress-activated protein kinases,CIKS） , is a recently identified molecule, which activates NF-KB . Recent studies have shown that Actl is a key positive regulator of IL-17 signaling pathway,and an important negative regulator of B cell-mediated humeral immune responses through its function in CD40L and BAFF signaling. Actl is critical for TH17 and B cell mediated autoimmune and inflammatory responses. Moreover, Actl may play important roles in ontogenesis. Such seemingly opposite functions of Actl in CD40-BAFFR and IL-17R signaling are orchestrated by different domains in Actl. Such delicate regulatory mechanisms may provide a common vehicle to promote balance between host defense to pathogens and tolerance to self.