复方肝舒贴的体外释放研究

本文旨在研究复方肝舒药物的体外释放速度和药物中化学成分自身经皮渗透特性。复方肝舒用医用胶制备成为贴剂，体外释放速度和经皮渗透特性分别通过药典释放度方法和Franz扩散池法进行考察。体外释放研究结果表明，复方肝舒贴制剂中黄芪甲苷在2h释放率约为5％，12h释放超过70％，此后释放速度逐渐放缓；莪术醇24h累计释放超过50％；没药和王不留行中成分也有不同程度释放。经皮渗透结果表明，莪术、郁金和没药中所合成分能够穿过裸鼠皮肤。

Study on release of compound Ganshu patches

The es,such objective of this paper was to investigate the in vitro release of the consituents of compound Ganshu patchas astragalosides,curcumol and vacsegoside etc,A pharmacopoeia method for in vitro drug release and a Franz diffusion means were utilized for the determination of the in vitro drug release of constituents from patch formulations and the permeability of constituents per se respectively.Results showed that about 5% and 70% of astragaloside were released from the tested formulations in 2 h and 24 h respectively when further increasing release time led to a decreased release rate,whereas morethan 50% of curcumol were released in 24 h.In addtion,other constituents were also found to be released to some extent in 30 h.Diffusion results suggested that lipophilic ingredients per se,such as curcumol,could penetrate through the hairless mouse skin,whereas those hydrophilic compounds,such as astragalosides,possessed limited permeability.