| Infliximab联合免疫球蛋白治疗噬血细胞综合征疗效观察 |
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| 引用本文： | 周慷,娄世峰,陈林. Infliximab联合免疫球蛋白治疗噬血细胞综合征疗效观察[J]. 现代医药卫生, 2010, 26(7): 976-978 |
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| 作者姓名： | 周慷 娄世峰 陈林 |
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| 作者单位： | 重庆医科大学附属第二医院血液科,重庆,400010 |
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| 摘 要： | 目的:观察抗肿瘤坏死因子单克隆抗体(infliximab)联合免疫球蛋向治疗噬血细胞综合征疗效.方法:大剂量免疫球蛋白(10 g/dx4 d)联合2次Infliximab(100mg/d).结果:1例有多个脏器功能损害的患者诊断为柯萨奇病毒感染合并噬血细胞综合征,治疗后病情完全缓解.结论:噬血细胞综合征本身只是一种过度免疫反应,infliximab可能成为阻断细胞因子的重要治疗手段.
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| 关 键 词： | 噬血细胞综合征 Infliximab 肿瘤坏死因子 |
Clinical observation on therapeutic effect of infliximab and immunoglobulin on patient with hemophagocytic lymphohistiocytosis |
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| ZHOU Kang , LOU Shi-feng , CHEN Lin. Clinical observation on therapeutic effect of infliximab and immunoglobulin on patient with hemophagocytic lymphohistiocytosis[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2010, 26(7): 976-978 |
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| Authors: | ZHOU Kang LOU Shi-feng CHEN Lin |
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| Affiliation: | ZHOU Kang,LOU Shi-feng,CHEN Lin(Department of Hematology,Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | Objective：to observe the therapeutic effect of infliximab and immunoglobulin on the patient with hemophagocytic lym- phohistiocytosis （HLH）.Methods：Infliximab（100mg/day） was administered twice and immunoglobulin （10 g/d×4 d） was administered.Results ： A 20-year-old woman diagnosed with HLH,attained remission.Conclusion： For HLH patients, anticytokine treatment with infliximab may represent one of promising options. |
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| Keywords: | Hemophagocytic lymphohistiocytosis Tumor necrosis factor-α（TNF-α） infliximab |
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