| 异基因骨髓移植后肾病综合征的临床与病理分析 |
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| 引用本文： | 乔晞,李荣山,王利华,吴丽然,赵惠琴,卫建平.异基因骨髓移植后肾病综合征的临床与病理分析[J].山西医科大学学报,2008,39(10). |
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| 作者姓名： | 乔晞 李荣山 王利华 吴丽然 赵惠琴 卫建平 |
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| 作者单位： | 1. 山西医科大学第二临床医学院肾内科,太原,030001
2. 山西医科大学第二临床医学院病理科 |
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| 摘 要： | 目的探讨异基因骨髓移植后肾病综合征的临床和病理特点。方法对1例异基因骨髓移植后发生肾病综合征患者的临床、病理资料及治疗进行综合分析。结果本例患者在骨髓移植后28个月发生肾病综合征，在此之前患者有皮肤、口腔和肝脏损害表现；肾脏病理表现为膜性肾病。糖皮质激素及霉酚酸酯治疗后肾病综合征完全缓解。结论异基因骨髓移植后肾病综合征是慢性移植物抗宿主病的肾脏表现，可能为自身免疫性疾病，是移植物对宿主产生的一种排斥反应。肾穿刺活检对该病的诊断和预后判断具有重要价值，免疫抑制剂治疗有效。
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| 关 键 词： | 骨髓移植 慢性移植物抗宿主病 肾病综合征 |
Clinicopathological analysis of nephrotic syndrome after allogeneic bone marrow transplantation |
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| QIAO Xi,LI Rong-shan,WANG Li-hua,WU Li-ran,ZHAO Hui-qin,WEI Jian-ping.Clinicopathological analysis of nephrotic syndrome after allogeneic bone marrow transplantation[J].Journal of Shanxi Medical University,2008,39(10). |
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| Authors: | QIAO Xi LI Rong-shan WANG Li-hua WU Li-ran ZHAO Hui-qin WEI Jian-ping |
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| Institution: | 1Dept of Nephrology;Second Clinical Medical College;Shanxi Medical University;Taiyuan 030001;China;2Dept of Pathology;Shanxi Medical University |
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| Abstract: | Objective To investigate the clinicopathological characteristics of nephrotic syndrome after allogeneic bone marrow transplantation.Methods Clinical and pathological data from a patient with nephrotic syndrome after allogeneic bone marrow transplantation were analyzed.Results The patient developed nephrotic syndrome at month 28 after allogeneic bone marrow transplantation.Other manifestations including skin,mouth and liver damages were observed before nephrotic syndrome.Glomerular histology revealed membran... |
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| Keywords: | bone marrow transplantation chronic graft versus host disease nephrotic syndrome |
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