重度子痫前期患者血清孕酮水平的研究

目的：探讨重度子痫前期患者外周静脉血清中孕酮水平与正常妊娠孕妇的差异。方法选择重度子痫前期的单胎妊娠妇女共52例为重度子痫前期组；选择同期正常单胎妊娠妇女共50例为对照组。住院患者于入院后当日或第二日收集其空腹外周静脉血标本，门诊患者于就诊当日收集其空腹外周静脉血标本，孕酮测定采用电化学发光免疫分析仪测定。结果对照组血清孕酮含量为（139.71±16.65） ng／ml；重度子痫前期组血清孕酮含量为（118.03±16.77）ng／ml ，二者比较差异有统计学意义。结论重度子痫前期患者外周血血清孕酮水平明显低于正常妊娠妇女，推测血清孕酮水平降低通过干扰免疫因素，参与了重度子痫前期的发病过程。

The study about serum progesterone levels of patients with severe preeclampsia

Objective To investigate the differences of serum progesterone levels between normal pregnancy women and se‐vere preeclampsia patients .Methods 52 patients with severe preeclampsia were enrolled in the study group ,while the 50 women with normal pregnancy were enrolled in the control group .Fasting peripheral venous blood samples of all cases were col‐lected for measurement at the acquisition date by electrochemiluminescence immunoassay analyzer .Results Serum progesterone levels in the study group (118 .03 ± 16 .77) ng/ml was significantly lower than those in control group (139 .71 ± 16 .65) ng/ml . Conclusion Serum progesterone levels were significantly lower in severe preeclampsia patients than in normal pregnant women . The hypothese was that low progesterone was involved in the pathogenesis of severe preeclampsia by interfering with immune factors .