| 胃滞留漂浮型缓控释制剂的研究概况 |
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| 引用本文： | 曲莉,王智民,仝燕.胃滞留漂浮型缓控释制剂的研究概况[J].中国实验方剂学杂志,2006,12(7):66-70. |
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| 作者姓名： | 曲莉 王智民 仝燕 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700;江西中医学院,江西,南昌,330004
2. 中国中医科学院中药研究所,北京,100700 |
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| 摘 要： | 综述了胃滞留漂浮型缓控释给药系统的释药原理、漂浮性能的影响因素及制剂质量评价等方面的内容。根据近十年来国内外文献报道介绍胃滞留漂浮型缓控释制剂的研究进展情况，阐述了制剂主要适用于在胃部或者小肠上部有特定吸收或具有专属性治疗等药物，通过延长药物在胃肠道内的滞留时间来提高药物的生物利用度和有效性；因此该制剂具有广阔的发展前景。
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| 关 键 词： | 胃滞留 漂浮 缓控释制剂 |
| 文章编号： | 1005-9903（2006）07-0066-05 |
| 收稿时间： | 2005-08-03 |
| 修稿时间： | 2005年8月3日 |
Advance on Controlled-and Sustained-release Dosage Forms Remaining Floating in Stomach with Prolonged Gastric Resident Time |
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| QU Li,WANG Zhi-min,TONG Yan.Advance on Controlled-and Sustained-release Dosage Forms Remaining Floating in Stomach with Prolonged Gastric Resident Time[J].China Journal of Experimental Traditional Medical Formulae,2006,12(7):66-70. |
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| Authors: | QU Li WANG Zhi-min TONG Yan |
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| Institution: | 1. Institute of China Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China ; 2. Jiangxi University of Traditional Chinese Medicine, Jiangxi Nanchang 330006, China |
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| Abstract: | This paper reviews the theory of releasing drugs on floating sustained-release dosage forms for gastric retention and influential factors of floating and evaluation on dosage quality control. According to the development on the dosage forms in recent decades, such retention systems are important for drugs that are best for absorption in the stomach or upper the intestine as well as for controlling release of the drugs having site-specific absorption limitations. Retention of drug delivery system in stomach prolongs overall gastrointestinal transit time, thereby resulting in improved bioavailability and efficiency for some drugs. |
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| Keywords: | Gastric retention Floating Controlled- and sustained-release dosage forms |
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