| 首茸方对利血平小鼠脑内多巴胺及其代谢产物的影响 |
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| 引用本文： | 王巍,赵德忠,孙晓芳,谷胜东. 首茸方对利血平小鼠脑内多巴胺及其代谢产物的影响[J]. 中国中药杂志, 2002, 27(5): 368-370 |
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| 作者姓名： | 王巍 赵德忠 孙晓芳 谷胜东 |
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| 作者单位： | 中国中医研究院,西苑医院,北京,100091 |
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| 摘 要： | 目的 :探讨在临床可协同西药治疗帕金森病 (PD)的首茸方的药效作用。方法 :利血平皮下注射造成小鼠PD模型 ,应用高效液相色谱 电化学 (HPLC-EC)检测器测定小鼠脑匀浆中多巴胺 (DA)及其代谢产物的水平。结果 :发现美多巴可以提高PD小鼠脑内DA的水平 ,首茸方与美多巴合用后 ,小鼠脑内的DA水平不仅明显高于模型组而且高于美多巴组。结论 :首茸方可以协同美多巴增加脑内DA的含量 ,提高美多巴的疗效 ,可减少美多巴的用量 ,降低其副作用。
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| 关 键 词： | 首茸方 帕金森病 多巴胺 高效液相色谱电化学检测器 |
| 文章编号： | 1001-5302(2002)05-0368-03 |
| 收稿时间： | 2001-04-07 |
| 修稿时间： | 2001-04-17 |
The Effect of Shourong Compound Formula on Levels of Dopamine and Its Metabolites in Brain of Parkinson''s Disease Mice Induced by Reserpine |
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| WANG Wei;ZHAO De zhong;SUN Xiao fang;GU Sheng dong. The Effect of Shourong Compound Formula on Levels of Dopamine and Its Metabolites in Brain of Parkinson''s Disease Mice Induced by Reserpine[J]. China Journal of Chinese Materia Medica, 2002, 27(5): 368-370 |
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| Authors: | WANG Wei ZHAO De zhong SUN Xiao fang GU Sheng dong |
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| Affiliation: | Xiyuan Hospital, China Academy of TCM, Beijing 100091, China. |
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| Abstract: | Objective: To investigate the effect of Shourong compound formula on treating Parkinson's disease. Method: Parkinson's disease model mice induced by reserpine was used and by HPLC ED the levels of Dopamine (DA) and its metabolites were determined. Result: Madopar could increase the levels of DA in brain of PD mice. The effect of madopar together with Sourong compound formula was better than that of madopar(P<0.001). Conclusion: Shourong compound formula together with madopar has synergic effect on increase of DA level in brain and can reduce clinic dose of madopar so that side effect of madopar can be decreased. |
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| Keywords: | shourong compound formula Parkinson's disease dopamine high pressure liquid chromatography with electrochemical detection |
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