甜茶的急性和长期毒性研究

目的 :研究甜茶的急性和长期毒性。方法 :采用急性经口毒性和长期毒性法。结果 :小鼠急性经口毒性试验 ,雌雄性小鼠经口 L D50 >2 1 5 0 0 m g/ kg。大鼠长期毒性试验 ,用 5 0 0 0 m g/ kg、1 0 0 0 0 m g/ kg、2 0 0 0 0 m g/ kg.bw的甜茶给大鼠连续灌胃 30天 ,未观察到中毒表现。甜茶各剂量组动物体重、增重、食物利用率 ,血液学和血液生化学指标值 ,各脏器的脏 /体比值与空白对照组比较均无显著差异 (P>0 .0 5 )。主要脏器在外观形态和组织学上均无异常变化。结论 :甜茶对大鼠的生长发育 ,造血功能 ,肝肾功能 ,器官组织均无明显毒性

Acute and chronic toxicity of Rubus suavissimus

Objective:To study the acute and chronic toxicity of Rubus suavissimus Methods:Acute and chronic toxicological tests were performed by oral administration Results:Acute oral test in mice of both sexes showed LD 50 >21500mg/kg;No toxic responses were found in chronic test in rats of both sexes at doses of 5000mg/kg,10000mg/kg and 20000mg/kg.bw by oral administration for 30 days.No significant difference between the control group and respective tested group( P >0 05)was observed in indices of body weight,growth,feed availability,hematology and blood biochemistry,and the weight ratio of organ/body.In addition,organ outline and histological examination by microscopy were not found abnormally changed Conclusion:Rubus suavissimus has no toxicity on the development,hematology, functions of liver and kidney and histology in rats