SPECT脑血流灌注断层显像在新生儿缺氧缺血性脑病的初步应用

目的了解新生儿缺氧缺血性脑病（ＨＩＥ）局部脑血流（ｒＣＢＦ）的变化规律，探讨临床表现与ｒＣＢＦ的关系。方法采用锝（９９ｍＴｃ）乙撑双半胱氨酸二乙酯（ＥＣＤ）单光子发射型计算机断层摄影术（ＳＰＥＣＴ）对６７例ＨＩＥ患儿进行脑血流灌注断层显像。结果ＨＩＥ轻度组显像异常率为２０％，中度组７７％，重度组９２％，总异常率为６３％。中、重度组常有２个以上部位异常。结论ＨＩＥ病情轻重与ｒＣＢＦ的变化一致。脑血流灌注断层显像可为探讨ＨＩＥ发病机理和早期诊断提供依据

Preliminary application of 99m Tc ECD SPECT in neonatal hypoxic ischemic encephalopathy

Objective To understand the changes of regional cerebral blood flow (rCBF) in neonates with hypoxic ischemic encephalopathy (HIE) and the relationship between the changes in rCBF and the clinical manifestations. Methods Technetium 99m ( 99m Tc) ECD single photon emission computed tomography (SPECT) was performed in 67 newborns with HIE. Results The SPECT was abnormal in 20% of neonates with mild HIE, 77% of neonates with moderate HIE, and 92% with severe HIE; the total abnormality rate was 63%. There were usually two or more abnormal cerebral areas in the moderate and the severe groups. Conclusion The clinical manifestation of HIE is consistent with changes in rCBF, and 99m Tc ECD SPECT can furnish evidence for studying pathogenesis of HIE and making early diagnosis.