| 汉防己甲素对环孢素A药物动力学参数的影响 |
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| 引用本文： | 孙成春,张莉,王景祥.汉防己甲素对环孢素A药物动力学参数的影响[J].中国医院药学杂志,1998,18(11):500-501. |
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| 作者姓名： | 孙成春 张莉 王景祥 |
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| 作者单位： | 济南军区总医院,济南250031 |
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| 摘 要： | 目的：汉防己甲素对环孢素Ａ药物动力学参数的影响。方法：采用荧光偏振免疫分析法（ＦＰＩＡ）对单用环孢素Ａ（ＣｓＡ）及ＣｓＡ与汉防己甲素（Ｔｅｔ）合用后，家兔体内ＣｓＡ全血药物浓度进行了测定，并对两组药动学参数进行了统计学处理。结果：Ｔｅｔ可使ＣｓＡ的ＡＵＣ略有增大，合并给药组与对照组比较Ｃｍａｘ差异有显著性（Ｐ＜０．０５），其余药动学参数无显著变化。结论：ＣｓＡ与Ｔｅｔ合用可行，并可减轻ＣｓＡ的毒副作用
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| 关 键 词： | 环孢素A，汉防己甲素，药动学参数 |
Effect of tetrandring on cyclosporine pharmacokinetics |
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| Sun Chengchun,Zhang Li,Wang Jingxiang.Effect of tetrandring on cyclosporine pharmacokinetics[J].Chinese Journal of Hospital Pharmacy,1998,18(11):500-501. |
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| Authors: | Sun Chengchun Zhang Li Wang Jingxiang |
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| Abstract: | Aim:Cyclosporine in the whole blood was determined by FPIA for rabbits having taken cyclosporine or cyclosporine with tetrandrine.Method:The two groups of pharmacokinetics parameters were computed by statistic method.Results:The AUC of cyclosporine could be slightly increased by tetrandrine,the C max of combined groups had significal change( P < 0.05 ) the other pharmacokinetics parameters were not significant change.Conclusion:The adverse drug reaction might be reduced by use of the combination. |
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| Keywords: | cyclosporine tetrandrine pharmacokinetics parameters |
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