EGFR mutation status in primary lung adenocarcinomas and corresponding metastatic lesions: discordance in pleural metastases |
| |
Authors: | Han Hye-Suk Eom Dae-Woon Kim Joo Heon Kim Kyung-Hee Shin Hyang-Mi An Jin Young Lee Ki Man Choe Kang Hyeon Lee Ki Hyeong Kim Seung Taik Koo Ji Hae Lee Ho-chang Lee Ok-Jun |
| |
Affiliation: | 1Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea;2Department of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea;3Department of Pathology, Eulji University School of Medicine, Daejeon, Korea;4Department of Pathology, Chungnam National University, School of Medicine, Daejeon, Korea;5Department of Pathology, Cheongju St. Mary's Hospital, Cheongju, Korea;6Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea |
| |
Abstract: | IntroductionThe aim of this study was to compare epidermal growth factor receptor (EGFR) and KRAS mutations between primary tumors and corresponding metastases including pleural metastases in lung adenocarcinoma.MethodsThirty-seven paired primary lung adenocarcinomas and corresponding metastatic tumors were analyzed for EGFR and KRAS mutations. In addition, 21 pleural metastases including malignant pleural effusion or pleural biopsy were used in performing these mutation analyses.ResultsEGFR mutations were detected in 18 primary lung adenocarcinomas (48.6%) and in 16 corresponding metastases (43.2%). EGFR mutations showed a discordance rate of 16.2% (6 of 37 patients) between primary lung adenocarcinomas and corresponding metastases. Among 21 pleural metastases, 3 patients (14.3%) showed that the EGFR mutation was discordant. KRAS mutations were detected in one primary tumor and in two metastatic tumors. Eighteen patients were treated with EGFR tyrosine kinase inhibitors. One of seven patients who experienced partial response had EGFR mutations only in the metastasis, and two of seven patients who experienced progressive disease carried wild-type EGFR only in the metastasis.ConclusionsEGFR mutations were discordant between primary tumors and corresponding metastases in a significant portion of lung adenocarcinomas. Furthermore, these discordance was also observed in metastases to the pleura, the nearest metastatic site. |
| |
Keywords: | Epidermal growth factor receptor Lung adenocarcinoma Metastasis Mutation Pleura |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|