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No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease |
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| Authors: | P. Friedrich,T.M. Feulner,S.M. Laws,K. EckartR. Perneczky,A. KurzH. Fö rstl,M. Riemenschneider |
| Affiliation: | a Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-München, Munich, Germany b Centre of Excellence for Alzheimer's Disease Research and Care, Sir James McCusker Alzheimer's Disease Research Unit, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia c Department of Psychiatry and Psychotherapy, TU-München, Munich, Germany d Department of Psychiatry and Psychotherapy, Universität des Saarlandes, Homburg, Saar, Germany |
| Abstract: | The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in stress induced hippocampal acetylcholine release and the gene TACR2 is located within a previously identified linkage region for Alzheimer's disease (AD) on chromosome 10q21. Together, both facts make the TACR2 a reasonable positional and functional candidate gene for AD. Genotyping of 13 single nucleotide polymorphisms (SNPs) covering the entire gene and haplotypic analysis revealed no association with AD. Thus, we conclude that TACR2 can be excluded as a major susceptibility gene conferring risk to AD. |
| Keywords: | Alzheimer's disease Genetics Tachykinin receptor TACR2 |
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