Thrombotic microangiopathy |
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| Authors: | M. Mö rtzell,G. Berlin,T. Nilsson,C.G. Axelsson,M. Efvergren,J. Audzijoni,A. Griskevicius,J. Ptak,M. Blaha,H. Tomsova,G.M. Liumbruno,P. Centoni,E. Newman,S. Eloot,A. Dhondt,J. Tomaz,V. Witt,G. Rock,B. Stegmayr |
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| Affiliation: | aDepartment of Public Health and Medicine, Umeå University, Umea, Sweden;bDepartment of Transfusion Medicine, University Hospital, Linkoping, Sweden;cDepartment of Internal Medicine, University Hospital, Uppsala, Sweden;dDepartment of Transfusion Medicine, University Hospital, Orebro, Sweden;eDepartment of Nephrology, University Hospital Karolinska, Huddinge, Sweden;fDepartment of Transfusion Medicine, University Hospital, Vilnius, Lithuania;gDepartment of Haematology, County Hospital, Frydek-Mistek, Czech Republic;hDepartment of Hematology, II Internal Clinic, University Hospital, Hradec Kralove, Czech Republic;iDepartment of Immunohaematology, Transfusion Medicine and Clinical Pathology, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy;jDepartment of Transfusion Medicine, University Hospital, Livorno, Italy;kDepartment of Haematology, Concord Repatriation General Hospital, Concord, Australia;lDepartment of Nephrology, University Hospital of Ghent, Ghent, Belgium;mDepartment of Transfusion Medicine, University Hospital, Coimbra, Portugal;nDepartment of Haematology and Oncology, St. Anna Kinderspital, University Hospital, Vienna, Austria;oDepartment of Haematology, University Hospital, Ottawa, Canada |
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| Abstract: | Thrombotic microangiopathy (TMA) is a histopathological feature of various diseases including thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). There are many secondary causes of TMA, many of them could mimic TTP or HUS. This article presents a short overview on TMA. In conclusion TMA is the result of various etiology reasons and pathologic reactions with various clinical entities. It is important to focus on a thorough history including family history when deciding on a diagnosis. Analysis of ADAMTS 13 and ADAMTS 13-antibodies may help to decide continued therapy. |
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| Keywords: | Thrombotic microangiopathy Hemolytic uremic syndrome ADAMTS13 TMA TTP HUS |
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