山首丹煎剂对实验动物的降脂保肝作用

目的观察山首丹(shanshoudan,SSD)煎剂对实验性高脂血症小鼠的降血脂、肝脂及肝脏功能的保护作用,为临床应用提供理论依据。方法采用高脂饲料建立小鼠高脂血症脂肪肝模型。实验分为正常对照组、模型组、山首丹煎剂(高、中、低)剂量组和阳性对照组(东宝肝泰)。以高、中、低剂量山首丹煎剂和东宝肝泰对高脂血症脂肪肝小鼠进行干预,然后测定各组小鼠的血脂、肝脂、肝指数、肝功能及形态变化。结果SSD煎剂对高脂小鼠血清中TC、TG、LDL-C均有明显降低(P<0.05),且有剂量依赖性。血清中HDL-C变化不明显,但有良好的变化趋势。对肝脂降低明显(P<0.05或P<0.01),能改善高脂饲料小鼠的肝功能,表现在血清中AST、ALT含量明显降低(P<0.05),肝细胞中SOD活性有增高趋势,但无显著性(P>0.05);肝脏功能镜检SSD各组均好于高脂饲料模型组。结论SSD煎剂对高脂饲料小鼠有较好的降血脂、肝脂及肝脏保护作用。

The Effect on Lipid in Serum and Liver of Fatty Liver Mice with Hyperlipermia by Shanshoudan decoction

Objective To observe the effect of shanshoudan decoction(SSD) on the content of lipid serum and liver of fatty liver mices with hyperlipemia,and provide a new therapeutic method to hyperlipemia fatty liver.Methods To feed the mices with high fat diet and duplicate the model of fatty liver.Mices were randomly divided into six groups(nomal group,model group,SSDgrouphigh dose,middle dose,low dose],dongbaogantai group).Blood lipid,hepatic lipid,hepatic index,hepatic function,and liver were assayed respectively before and after therapy with SSD.Results SSD can remarkably decrease the content of total cholesterin(TC),triglyceride(TG),low density lipoprotein(LDL-c) in the serum of the model mices in a dose-dependent manner;the levels of high density lipoprotein(HDL-c) was insignificant compared with the hyperlipemia model group but had the decreasing tendency.SSD also increased hepatic lipid significantly(P<0.05 or P<0.01) and improved the hepatic of function.As the content of AST,ALT in serum decreased remarkably(P<0.05),increased SOD activities(P<0.05),meanwhile hepatic histology observed under optical microscope was better than model group.Conclusions SSD has a better effect by adjusting serum lipid,hepatic lipid and resisting fatty liver.