Paraproteinaemia plus osteolytic lesions in typical hairy-cell leukaemia |
| |
| Authors: | J. Jansen R. L. H. Bolhuis J. A. van Nieuwkoop H. R. E. Schuit W. F. Stenfert Kroese |
| |
| Affiliation: | J. A. Cohen Institute for Radiopathology and Radiation Protection;Department of Haematology, Leiden University Medical Centre, Leiden;Divisions of Immunology Daniel den Hoedkliniek and Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands;Department of Immunohaematology, Leiden University Medical Centre, Leiden;Department of Pathology, Leiden University Medical Centre, Leiden;Haematology, Daniel den Hoedkliniek and Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands |
| |
| Abstract: | Most cases of hairy-cell leukaemia (HCL) involve proliferations of neoplastic B lymphocytes. In rare cases, M-proteins or osteolytic lesions have been documented in patients with HCL. In this study two patients with typical HCL are reported in whom both paraproteinaemia and osteolytic lesions of the femoral neck developed. In one of the patients the production of the M-protein by hairy cells could be established. In the other patient, at autopsy no signs of myeloma were found. The hairy cells from inside the osteolytic lesion had the same immunological phenotype as hairy cells from the peripheral blood, the spleen, and other parts of the bone marrow. These cases once more confirm the B-cell nature of many cases of HCL, and show that hairy cells can have functional capacities usually attributed to much more mature B lymphocytes, i.e. plasma cells. |
| |
| Keywords: | |
|
|
