| 紫金砂化学成分研究 |
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| 引用本文： | 杨郁,于能江,张杨,任凤霞,张爱军,赵毅民. 紫金砂化学成分研究[J]. 中国药学杂志, 2010, 45(17): 1320-1322 |
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| 作者姓名： | 杨郁 于能江 张杨 任凤霞 张爱军 赵毅民 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京 100850 |
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| 摘 要： | 目的 研究紫金砂的化学成分。方法 药材采用体积分数80％乙醇提取,氯仿萃取,利用硅胶柱,RP-18反相柱,Sephadex LH-20凝胶柱分离纯化,并根据理化性质和波谱数据进行结构鉴定。结果 分离鉴定13个化合物,分别为异欧前胡素（1）、水合氧化前胡素内酯（2）、拐芹色原酮（3）、佛手柑内酯（4）、欧前胡素（5）、ledebouriellol（6）、二氢欧山芹素（7）、isopimpinellin（8）、osthol（9）、3′(R)-+-亥茅酚（10）、oxypeucedanin ethanolate（11）、β-谷甾醇（12）、豆甾醇（13）。结论 化合物6~11为首次从紫金砂中分离得到,其中化合物6、11为首次从当归属植物中分离得到。
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| 关 键 词： | 紫金砂 当归属 化学成分 |
| 收稿时间： | 2012-01-01; |
Studies on Chemical Constituents of Angelica polymorpha Maxim. |
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| YANG Yu,YU Neng-jiang,ZHANG Yang,REN Feng-xia,ZHANG Ai-jun,ZHAO Yi-min. Studies on Chemical Constituents of Angelica polymorpha Maxim.[J]. Chinese Pharmaceutical Journal, 2010, 45(17): 1320-1322 |
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| Authors: | YANG Yu YU Neng-jiang ZHANG Yang REN Feng-xia ZHANG Ai-jun ZHAO Yi-min |
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| Affiliation: | Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850, China |
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| Abstract: | OBJECTIVE To study the chemical constituents of Angelica polymorpha Maxim. METHODS The chloroform-soluble fraction of alcohol-extract was isolated and purified by column chromatography on silicagel,RP-18 and Sephadex LH-20 column. All compounds were identified on the basis of spectral analysis and physico-chemical characters. RESULTS Thirteen compounds were isolated and identified as isoimperatorin (1),aviprin (2),angeliticin A (3),bergapten (4),imperatorin (5),ledebouriellol (6),columbianadin (7),isopimpinellin (8) ,osthol (9) ,3′(R)-+-hamaudol (10) ,oxypeucedanin ethanolate (11) ,β-sitosterol (12) and stiamasterol (13). CONCLUSION Compounds 6-11 were isolated from this plant for the first time. Compound 6 and 11 were isolated from this genus for the first time. |
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| Keywords: | Angelica polymorpha Maxim')" href=" #" > Angelica polymorpha Maxim Angelica')" href=" #" > Angelica chemical constituents |
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