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Evaluation of a P,N‐ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds |
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| Authors: | Mégane Valero Annina Burhop Kristof Jess Remo Weck Matthias Tamm Jens Atzrodt Volker Derdau |
| Institution: | 1. R&D, Integrated Drug Discovery, Isotope Chemistry and Metabolite Synthesis, Sanofi, Frankfurt/Main, Germany;2. Institut für Anorganische und Analytische Chemie, Technische Universit?t Braunschweig, Braunschweig, Germany |
| Abstract: | We have developed a novel and efficient iridium‐catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient temperatures. Furthermore N‐oxides and phosphonamides have been successfully applied in hydrogen isotope exchange reactions with moderate to excellent deuterium introduction. |
| Keywords: | catalysis deuterium hydrogen isotope exchange iridium |