Synthesis of carbon‐14 labeled ZJ0712, a novel strobilurin fungicide |
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| Authors: | Zheng‐Min Yang Ya‐Jun Xu Gui‐Hua Zhang Cai‐Guang Jian Xiao Li Qing‐Fu Ye |
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| Affiliation: | 1. Radiosynthesis Research Center, Shanghai Qizhen Isotech Co, Ltd, Shanghai, China;2. Institute of Nuclear‐Agricultural Science, Zhejiang University, Hangzhou, China |
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| Abstract: | ZJ0712, a broad‐spectrum fungicidal ingredient of strobilurin, exhibits a high protective and curative activity against plant pathogenic fungi. To support the study on its metabolism, residue, environmental behavior, and fate for safety evaluation, two versions of carbon‐14 labeled ZJ0712, methyl (E)‐2‐(2‐((2,5‐dimethylphenoxy)methyl)phenyl)‐3‐methoxy[2‐14C]acrylate ( 2 ) and methyl (E)‐2‐(2‐((2,5‐dimethyl[phenyl‐U‐14C6]phenoxy)methyl)phenyl)‐3‐methoxyacrylate ( 3 ), were synthesized from barium [14C]carbonate in 6‐step yield of 47% and from 2,5‐dimethyl[phenyl‐U‐14C6]phenol in the yield of 91%, respectively. |
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| Keywords: | carbon‐14 isotopically labeled synthesis methyl (E)‐2‐(2‐((2,5‐dimethylphenoxy)methyl)phenyl)‐3‐methoxyacrylate strobilurin fungicide |
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