傣药波波罕的生物碱成分研究

目的:研究傣药"波波罕"—地不容(Stephania epigaea)的生物碱成分。方法:利用硅胶、凝胶等色谱技术对傣药波波罕块根2%的稀硫酸提取物进行分离纯化,利用波谱学阐明结构。结果:从波波罕块根中分离得到10个生物碱类成分,分别鉴定为千金藤碱(Stephanine,1)、凯萨斯新(Cassythicine,2)、荷包牡丹碱((-)-Dicentrine,3)、异可利定(Isocorydine,4)、青风藤碱(Sinoacutine,5)、青藤碱(Sinomenine,6)、8-甲氧基青藤碱(Cephamonine,7)、光千金藤碱(Stepholidine,8)、巴马汀(Palmatine,9)和四氢巴马汀(Tetrahydropalmatine,10)。结论:化合物7-9为首次从傣药波波罕中分离得到。

Studies on Alkaloids from the Stephania epigaea of Dai Traditional Medicine

Objective： To investigate the chemical constituents of Stephania epigaea. Methods： the pow- ered tuber were extracted with 2% H2SO4 -H20 and purified by silica gel and Sephadex LH -20 column chromatograph. The chemical structures were elucidated on the basis of spectral analysis and physico - chemical evidence. Results ： ten alkaloid compounds were obtained from the tuber of S. epigaea, they are characterized as stephanine （ 1 ）, （ - ） - cassythicine （2）, dicentrine （3）, isocorydine （4）, sinoacutine （5）, sinomenine （6）, cephamo- nine （7）, stepholidine （8）, palmatine （9） and tetrahydropalmatine （10）. Among them, compounds 7-9 were obetained for the first time from S. epigaea.