云南白药酊口服加外用的抗炎作用研究

目的:研究云南白药酊口服加外用的抗炎作用。方法:采用佐剂性关节炎以及尿酸钠致关节痛大鼠模型探讨云南白药酊的抗炎作用。结果:云南白药酊口服加外用能明显抑制佐剂性关节炎大鼠致炎足的原发肿胀以及对侧足的继发肿胀,降低前足红肿计分;云南白药酊口服或口服加外用给药能明显抑制尿酸钠致大鼠关节炎肿胀,并明显降低该模型大鼠步态计分。结论:云南白药酊对佐剂性关节炎以及尿酸钠所致关节炎症均有拮抗作用,口服加外用显示较好的协同作用。

Study the Anti-Inflammatory Effects of Yunnanbaiyao Tincture

Objective：To investigate the Anti-inflammatory effects of orally or topical plus intragastric administration of Yunnanbaiyao tincture in rats.Methods：The anti-inflammatory effect of Yunnanbaiyao tincture was investigated not only on rats model of adjuvant arthritis induced by Freund’s complete adjuvant,but also on joint pain caused by uric acid sodium.Results：The Yunnanbaiyao tincture were given by external or intragastric administration could significantly alleviate the primary swelling of on foot subjected to being injected Freund’s complete adjuvant,and also could extenuate secondary swelling on contralateral foot.At the same time,it could reduce to the swelling score of the forefoot.In rats model of joint pain caused by uric acid sodium,orally or topical plus intragastric administration of Yunnanbaiyao tincture could significantly inhibit the swelling of rat arthritis,and significantly reduce the gait score about rats.Conclusion：Intragastric or topical administration of Yunnanbaiyao tincture has obvious anti-inflammatory not only on rats model of adjuvant arthritis induced by Freund’s complete adjuvant,but also on joint pain caused by uric acid sodium.Topical plus intragastric administration of Yunnanbaiyao tincture shows a certain synergistic effects in some pharmacodynamic trials.Moreover,topical administration of Yunnanbaiyao tincture has positive effects on microcirculation in mice.