DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum |
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| Authors: | Kuo Li-Ming Yang Chen Kuei-Yuh Hwang Shy-Yuan Chen Jin-Liang Liu Yen-Yin Liaw Chia-Ching Ye Po-Ho Chou Cheng-Jen Shen Chien-Chang Kuo Yao-Haur |
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| Institution: | National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC. |
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| Abstract: | Recently, we found that the MeOH extract of Penicillium oxalicum showed inhibitory activity towards DNA topoisomerase I. Subsequently, ergosterol peroxide, ergosterol, palmitoleic acid, and linoleic acid were isolated from the cultured mycelia of P. oxalicum. The structural determinations were based on physical and spectral analyses. Biological evaluation revealed that ergosterol peroxide inhibited the relaxation of supercoiled DNA (pBR322) induced by DNA topoisomerase I, and also showed marginal, selective cytotoxic activity against human colon tumor cells COLO-205 (ED50=8.56 microg/mL]. |
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