| 槲皮素在兔体内的药代动力学 |
| |
| 引用本文： | 赵维中,戴俐明.槲皮素在兔体内的药代动力学[J].中国药理学通报,1992,8(6):452-455. |
| |
| 作者姓名： | 赵维中 戴俐明 |
| |
| 作者单位： | 安徽医科大学药理教研室 合肥230032
(赵维中，戴俐明，方明，马传庚，徐叔云)，安徽医科大学物理教研室 合肥230032
(冯仁骏)，安徽医科大学物理教研室 合肥230032(黄磊) |
| |
| 摘 要： | 槲皮素为黄酮类化合物。兔iv槲皮素10m g·kg~(-1)后.血药浓度—时间曲线符合二室模型。T_(1/2)(α)为2.91 ±1.36min,T_(1/2)(β)183.78±82.67min,V_B为0.624±0.225 L·kg~(-1),CL为3.15±2.11 ml·kg~(-1)·min~(-1).槲皮素10mg·kg~(-1)ig后,生物利用度为42.7％,药峰浓度(C_(Dk))为10.9mg·L~(-1),药峰时间(t_(pk))为60min。iv槲皮素后.药物以原型和代谢产物两种形式经尿、胆汁排泄,消除较迅速。
|
| 关 键 词： | 槲皮素 紫外分光光度法 药代动力学 |
The studies on pharmacokinetics of Quercetin in rabbits. |
| |
| ZHAO Wei -Zhong,DEI Li-Ming,MA Chuan -Geng.The studies on pharmacokinetics of Quercetin in rabbits.[J].Chinese Pharmacological Bulletin,1992,8(6):452-455. |
| |
| Authors: | ZHAO Wei -Zhong DEI Li-Ming MA Chuan -Geng |
| |
| Abstract: | The studies on pharmacoki-netics of Quercetin in rabbits were carried out by UV-spectrophotometry. The experimental results were shown that after 10mg · kg-1 of Quercetin iv administration in rabbits, the curve of plasma concentration - time was shown to fit an open two compartment model. The pharmacokinetic parameters were as follow:T1/2 (α) = 2. 91 ± 1. 36min,T1/2(β) = 183. 78±82. 67min,Vd=0. 624±0. 225L ???
kg-1,CL = 3. 15 ±2. llml · kg-1 · min-1. The bioavailability (F) of Quercetin after 10mg · kg-1 ig in rabbits was 42.7% and Cpk was 10. 9mg · L, tpk was 60min.
After 10mg · kg-1 iv administration in rabbits,Quercetin was rapidly eliminated from the blood. The compound and its metabolites were exereten by kidney and bile. |
| |
| Keywords: | Quercetin UV - spec-trophotometriy pharmacokinetics |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
