Platelet adhesion to smooth and rough hydrophobia and hydrophilic surfaces under conditions of static exposure and laminar flow |
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| Authors: | W Zingg AW Neumann AB Strong OS Hum DR Absolom |
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| Institution: | 1. Research Institute, Hospital for Sick Children, Toronto, Canada;2. Institute of Biomedical Engineering, University of Toronto, Toronto, Canada;3. Department of Mechanical Engineering, University of Toronto, Toronto, Canada;4. Department of Mechanical Engineering, University of Waterloo,Waterloo, Canada |
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| Abstract: | Platelet adhesion was measured on well-defined smooth surfaces and on the same surfaces with a known amount of roughness, under static conditions and in a new flow cell producing laminar flow. The results obtained with pig platelet suspensions show that under static conditions surface roughness does not influence platelet adhesion. With the flow cell an effect of roughness could be demonstrated, both with pig platelet suspension and with fresh canine blood: platelet adhesion decreased on a rough hydrophilic surface (glass) when compared with the same smooth surface, and increased on a rough hydrophobic surface (silane) when compared with the same smooth surface at the flow rates studied. |
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