A randomized, double blind study of the prophylactic effect of hyperbaric oxygen therapy on migraine |
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Authors: | Eftedal O S Lydersen S Helde G White L Brubakk A O Stovner L J |
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Affiliation: | Department of Circulation and Imaging, Norwegian University of Science and Technology, Trondheim, Norway. |
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Abstract: | In a double blind, placebo-controlled study to assess the prophylactic effect of hyperbaric oxygen therapy on migraine, 40 patients were randomly assigned to a treatment group receiving three sessions of hyperbaric oxygen, or a control group receiving three hyperbaric air treatments. The patients were instructed to keep a standardized migraine diary for eight weeks before and after the treatment. Thirty-four patients completed the study. Our primary measure of efficacy was the difference between pre- and post-treatment hours of headache per week. The results show a nonsignificant reduction in hours of headache for the hyperbaric oxygen group compared to the control group. Levels of endothelin-1 in venous blood before and after treatment did not reveal any difference between the hyperbaric oxygen and control groups. We conclude that the tested protocol does not show a significant prophylactic effect on migraine and does not influence the level of endothelin-1 in venous blood. |
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Keywords: | Migraine hyperbaric oxygen therapy endothelin |
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