药物性肝损害113例临床分析

目的探讨药物性肝损害的临床特点及预后相关因素。方法回顾性分析113例住院诊断为药物性肝损害的患者,分析其临床特点及预后相关因素。结果 113例药物性肝损害患者治疗有效率为66.37%,无效率33.63%;其中致肝损害药物前三位为中草药类,抗微生物药,抗结核药,分别占38.05%,20.35%,10.62%;TBil、ALP、ALB、PTA及并发症是影响疗效的相关因素。结论中草药和抗微生物药是目前药物性肝损害的主要药物;药物性肝损害的疗效与TBil、ALP、ALB、PTA及并发症有关。

Clinical analysis of 113 patients with drug-induced liver injury

Objective To research the clinical features and the prognostic factors of drug-induced liver injury（DILI）.Methods Retrospective analysis of 113 patients diagnosed as DILI was carried out to analyze the clinical features and the prognostic factors.Results The effective rate of therapy to the 113 patients with DILI was 66.37%,the inefficiency was 33.63%;the three most frequent drugs that cause liver damage are herbs,antimicrobial,anti-tuberculous drug,accounting for 38.05%,20.35%,10.62%,respectively;TBIL,ALP,ALB,PTA and the complications are the correlative factors influencing the curative effect.Conclusion Chinese herbal medicine and antimicrobial are the main drugs that cause liver damage;the curative effects for DILI are correlated with TBIL,ALP,ALB,PTA and the complications.