高温高湿环境下负压伤口疗法对创面愈合的影响

目的探讨高温高湿环境下局部负压伤口治疗对创伤愈合的影响。方法以兔背部皮肤全层皮肤缺损的急性创面为模型,将24只创伤兔按随机数字表法随机分为常温对照组、常温实验组、高温对照组、高温实验组,每组6只。实验组给予局部负压伤口治疗,对照组用纱布覆盖,不给予负压引流。在相应干预后的不同时间对各组动物的创面大体情况、创面愈合时间、创面愈合百分比、病理形态学进行观察和检测。结果高温对照组与常温对照组比较,创面愈合时间、创伤后7d创面愈合率、创面感染率及组织损伤程度显著增高（P〈0.05）,而实验组较相应的对照组则显著降低（P〈0.05）。结论高温高湿环境是阻碍创面愈合的重要因素之一,局部负压伤口疗法具有促进创面愈合的作用。

Influence of topical negative pressure wound therapy on wound healing in hot and humid environment

Objective To investigate the effects of topical negative pressure wound therapy （TNP） on the repair of acute wound under high temperature and high humidity condition. Methods After the acute whole-skin-loss wounds model of rabbit backside were established, a total of 24 rabbits were divided into 4 groups equally （6 rabbits each） and randomly as normal temperature control （NEC）, ordinary temperature experiment （NEE）, high-temperature control （HHC）, and high-temperature experiment （HHE）. The rabbits of HHE and NEE were treated with TNP, and the rabbits of HHC and NEC were treated with normal dressing. Indexes including general conditions of the wound surface, wound surface healing time, percentage of healed wound surface, and pathologi- cal changes of wound surface of all rabbits in different time points after intervention were observed. Results Compared with the normal environment （ NEC, NEE） , the wound healing time, the wound infecting rate, the percent of wound .healing at 7 d after injury and the changes of pathological morphology in high-temperature groups （ HHC, HHE） all increased significantly after trauma （ P 〈 0.05 ）. Compared with the control groups （ HHC, NEC）, this condition in the experiment groups decreased significantly after trauma （ P 〈 0.05 ）. Conclusion Ahigh temperature and high humidity circumstance is one of important influence factors that baffle the wound healing . The topical negative pressure wound therapy can efficiently hasten the processes of wound healing.