扁桃体原发性恶性淋巴瘤的免疫病理学特征

目的:探讨扁桃体原发性恶性淋巴瘤的类型特征和Ki-67、bcl-6及CD10的表达,阐明其生物学意义.方法:应用组织形态学和免疫组织化学方法,按照WHO造血和淋巴组织肿瘤第四版分类,复查50例扁桃体原发性恶性淋巴瘤的诊断并标记分类观察.结果:本组滤泡性淋巴瘤(FL) 37例,弥漫大B细胞淋巴瘤(DLBCL)9例,伯基特...

Immunopathological characteristics of tonsillar malignant iymphoma

Objective To study the subtypes of 50 cases of tonsillar malignant lymphoma and the expressions of Ki-67,bcl-6 and CD10 and explore their bilolgical significance.Methods By means of histomorphology and immunohistochemistry,50 cases of primary tonsillar biopsy were reviewed according to the new classification of WHO(2008).Results There were 37 cases of follicular lymphoma(FL),9 cases of diffuse large B-cell lymphoma(DLBCL),2 cases of Burkitt' s lymphoma(BL) and 2 cases of peripheral T-cell lymphoma(PTCL),16 cases of FL grade 1 and 2.The expression of Ki-67 was in 25%(4/16) of the indolent lymphoma,and 58.06%(18/31) of the aggressive lymphoma.The Ki-67 expression showed significant difference between different grades of malignancy(P<0.05).The variable expression of bcl-6 was in 88%(44/50) of NHL of tonsil.Coexpression of bcl-2+ and bcl-6+ in 40%(8/20)of the low grade FL,61.89%(13/21) of the high grade FL and 77.78%(7/9)of DLBCL.The CD10 expression showed statistical significance between genders(P<0.05).Conclusion All the cases of tonsillar malignant lymphoma are non-Hodgkin' s lymphoma.The most histological subtypes is FL,in turn DLBCL,BL and PTCL.There is a rising tendency of Ki-67 expression from low grade FL to aggressive DLBCL.The expressions of bcl-6 vary in different subtypes such as FL,DLBCL,BL and PTCL.There is an increase trend of bcl-2+ and bcl-6+ coexprssions in low grade FL,high grade FL and DLBCL in sequence.