肉苁蓉苯乙醇苷对东莨菪碱致记忆障碍小鼠保护作用的研究

目的：探讨肉苁蓉苯乙醇苷对东莨菪碱致学习记忆障碍小鼠的保护作用。方法：用高、低剂量（100 mg/kg、50 mg/kg）的肉苁蓉苯乙醇苷对东莨菪碱致记忆障碍模型小鼠进行灌胃,4周后用方形水迷宫检测学习和记忆能力,并测定脑组织内胆碱乙酰化酶（ChAT）及胆碱酯酶（AChE）含量、血清和脑组织中SOD含量、血清和肝组织中MDA含量。结果：与模型组比较,肉苁蓉苯乙醇苷组小鼠在方形水迷宫中的碰壁次数以及找到终点所需的时间都明显缩短,显示学习、记忆的错误次数降低,学习反应期缩短,记忆潜伏期延长;肉苁蓉苯乙醇苷能提高小鼠脑组织内ChAT和AChE的含量、改善胆碱能神经系统功能,提高小鼠血清和脑组织中的SOD含量以及降低血清和肝组织的MDA含量。结论：肉苁蓉苯乙醇苷具有提高学习、记忆能力。

A Study on the Effect of Phenylethanoid Glycosides of the Cistanche Deserticola on Scopolamine - induced Impairment of Learning memory in Mice

Objective： To investigate the effect of Phenylethanoid glycosides（PEG） of the Cistanche deserticola on learning memory impairment in mice induced by Scopolamine.Methods： Using square water maze to investigate the ability of the learning and memory of mice.After administration of high and low dose of the PEG,the learning and memory ability was assessed,and the content of ChAT,AchE in the brain tissues,SOD in both brain tissues and serum and MDA in the both serum and liver tissues were determined,respectively.Results： Compared with the model group,the learning and memorizing ability was improved in PEG groups.The concent of ChAT and SOD increased significantly.The AchE and MDA content in the brain tissues decreased.Conclusion： The PEG of Cistanche deserticola can enhance the ability of learning and memorizing.