p18 mRNA的表达与食管癌的关系

目的：研究食管癌患者p18 mRNA的表达，分析其表达与食管癌病理特征的关系，探讨p18基因在食管癌生长、转移中的作用。方法：选取34例经外科手术的食管癌患者（经术前及术后病理证实）食管癌组织作为实验组，同时选取34例食管癌患者的癌旁正常组织（癌旁正常组）和30例慢性胃炎患者内镜活检组织（慢性胃炎组）作为对照。采用原位...

Relationship between p18 mRNA expression and esophageal cancer

Objective To study the p18 mRNA expression in esophageal cancer patients and to analyze the relationship between the expression and pathological features of esophageal cancer,and to investigate the function of p18 gene in the growth and metastasis of esophageal cancer.Methods The cancer tissues from 34 esophageal cancer patients(confirmed by the pathology before and after surgery) after surgery were selected as experiment group.The normal tissues adjacent to cancer tissue from 34 patients and the endoscopic biopsy tissues form 30 chronic gastritis patients were used as control groups(adjacent normal group and chronic gastritis group).The expression of p18 mRNA was detected by in situ by bridization method,and the relationship between the p18 mRNA expression and the size of foci,the degree of invasion depth and lymph node metastasis were analyzed.Results Compared with adjacent normal group and chronic gastritis group,the expression of p18 mRNA in esophageal cancer group was increased(P<0.01),while there was no significant differences between adjacent normal group and chronic gastritis group(P>0.05);the expression of p18 mRNA in esophageal cancer tissues was related to the invasive depth,differentiation degree of cancer tissues and lymph node metastasis(P<0.05),which had nothing to do with the foci size(P>0.05).Conclusion p18 gene does not inhibit the growth of esophageal cancer,but inhibits its metastasis.p18 gene shows higher expression in esophageal cancer,which can be considered as a marker for diagnosis of esophageal cancer.