甲钴胺和胰激肽原酶肠溶片联用对糖尿病性周围神经病变的疗效观察

目的探讨作用机制不同的药物联合应用对糖尿病性周围神经病变（DPN）的疗效。方法将124例DPN患者随机分为两组，对照组应用甲钴胺，观察组应用甲钴胺和胰激肽原酶肠溶片。比较治疗前、后两组的临床症状和神经传导速度的差异。结果治疗后，两组的临床症状均缓解，神经传导速度增加；观察组临床症状的缓解和神经传导速度改善比对照组明显（P〈0．05，P〈0．01）。结论甲钻胺与胰激肽原酶肠溶片联合应用改善神经传导速度和缓解DPN症状的效果优于甲钴胺单用效果。

The therapeutic effect of combinative application of mecobalamine and pancreatic kininogenase enteric-coated tablets on diabetic peripheral neuropathy

Objective To observe the effect of combinative application of methycobalamin and pancreatic kininogenase enteric-coated tablets on diabetic neuropathy.Methods One hundred and twenty-four diabetic patients with peripheral neuropathy were randomly divided into two groups.One only received methycobalamin(control group,n=62)and the other did combinative application of methycobalamin and pancreatic kininogenase enteric-coated tablets(observation group,n=62).The clinical symptoms and nerve conduction velocity were compared between the two groups both pre-and post-treatment.Results After management,the symptoms improved and nerve conduction velocity increased in two groups(P<0.05).The improvement in symptoms and nerve conduction velocity was more obvious in observation group than control group(P<0.05,P<0.01).Conclusion The effectiveness of combinative application of methycobalamin and pancreatic kininogenase enteric-coated tablets for manageming DPN is better than single use of methycobalamin.