B细胞淋巴瘤干细胞的研究进展

 淋巴瘤干细胞的发生机制十分复杂多样。对于滤泡淋巴瘤（FL）和套细胞淋巴瘤（MCL）来说，有观点认为在骨髓中经V-D-J重排过的淋巴祖细胞（CLP）是其肿瘤干细胞（TSC）的来源；而在弥漫性大B细胞淋巴瘤（DLBCL）和散发性Burkitt淋巴瘤（BL）中，生发中心B细胞是TSC的来源。另一种观点是，表观遗传学改变一次打击使正常造血细胞重新获得干细胞功能，然后经过进一步的染色体易位使这些“前-淋巴瘤干细胞”最终成为淋巴瘤干细胞。分离与鉴定非霍奇金淋巴瘤（NHL）的TSC能够为NHL的发病机制和治疗研究提供新的认识。

Advance in research of B-cell lymphoma stem cells

Origin of lymphoma stem cells is very complicated,it is proposed that committed lymphoid progenitor/precursor cells (CLP) with V-D-J recombination are stem cells of follicular lymphoma (FL) and mantle cell lymphoma (MCL).Conversely,B lymphocytes within the germinal center as the diffuse large B-cell lymphoma (DLBCL) and sporadic Burkitt lymphoma (BL) stem cells.An alternative model supports an epigenetic modification of genes as the first occurring hit,which leads to retaining stem-cell features in hematopoietic cells, followed by secondary chromosomal translocations that eventually transformed into lymphoma.Isolation and characterization of the different B-cell non-Hodgkin lymphomas will provide critical insights into the disease pathogenesis and will represent a step towards the development of more effective therapies.