兰索拉唑、羟氨苄青霉素、替硝唑联合根除幽门螺杆菌的疗效观察

目的评价兰索拉唑（达克普隆）、羟氨苄青霉素、替硝唑三联疗法对幽门螺杆菌（Ｈｐ）相关性消化性溃疡的疗效。方法将８７例Ｈｐ阳性的十二指肠和（或）胃溃疡患者随机分为２组：第１组４３例，每次口服兰索拉唑３０ｍｇ、羟氨苄青霉素１０００ｍｇ、替硝唑５００ｍｇ，均每日２次，２周为一疗程；第２组４４例，给药方式同第１组，只是疗程缩短为１周，疗程结束后继续每日口服兰索拉唑３０ｍｇ，持续１周。疗程结束达４周时复查胃镜及Ｈｐ。３５例Ｈｐ根除后６个月行１４Ｃ－尿素呼气试验（ＵＢＴ）。结果第１组有３例因过敏性皮疹而退出观察，４０例用于统计学分析。第１组和第２组的Ｈｐ根除率分别为９００％和８１８％，十二指肠溃疡和胃溃疡的愈合率分别为９２５％和８８６％。６个月的Ｈｐ再感染率为８６％。结论第１组Ｈｐ根除率和溃疡愈合率均略高于第２组，两组相比差异无显著性（Ｐ＞００５）。两组均有较理想的溃疡愈合率和Ｈｐ根除率。

Effect of lansoprazoleamoxicillin and tinidazole triple therapy on Hp pylori eradication.

Objective\ To evaluate the triple therapy effect of lansoprazoleamoxicillin and tinidazole on the helicobacter pylori (Hp) associated digestive ulcer. Methods 87 Hp positive patients with duodenal and/or gastric ulcer were divided into two groups at random.The first group (43 cases) received two - week treatment with lansoprazole(30mg)amoxicillin(1 000mg) and tinidazole(500mg) twice daily.The second group received onweek treatment with the same methods as the first group,and continued to get one - week treatment of lansoprazole(30mg)once daily.Four weeks after completing this treatment,all patients had repeated Hp and endoscopic examination and 35 patients received 14\ C urea breath test. Results5BZ3 patients in the first group were excluded because of anaphylactic dermatitis,40 patients' results were analysed statistically.The eradication rate of the first and the second group was 90.0% and 81.8%,respectively.The duodenal and/or gastric ulcer healing rate of them was 92.5% and 88.6%,respectively.Hp repeatet infection rate (6 months after the treatment) was only 8.6%. Conclusion\ The Hp eradication and digestive ulcer healing rates of the first group were higher than that of the second group,but there is no significant difference between these two group(P>0.05).Our data showed that both groups had an ideal ulcer healing and Hp eradication rates after the triple therapy.