老年型阿尔茨海默病的病理与影像学对照研究

目的：我们通过4例老年型阿尔茨海默病（SDAT）的病理与其自身不同时期的影像学进行对照研究，探讨病理改变与影像的相关性。方法：病理用HE、Gallyas银染色及四种免疫组化方法，详细观察大脑皮层各叶、扣带回、杏仁核、海马、海马旁回、Meynert基底核、脑干的黑质、蓝斑、迷走神经背核的神经细胞丢失，老年斑、神经原纤维缠结等的变化。影像用4例剖检例自身生前不同时期的CT与病理的对照研究。结果：SDAT以颞叶及顶叶的变性为主：（1）额叶的皮质，以额叶中回的变性最明显；（2）岛叶的皮质，长回比短回的变性明显；（3）扣带回后性较前部变性明显，结论：SDAT的上述病理所见与影像学的改变基本一致。

A contrast on pathology and imaging in senile dementia of the Alzheimer type

Objective To explore the correlation of pathological changes and imaging through a control study on pathology and imaging of 4 cases of senile dementia of the Alzheimer type (SDAT).Methods By HE and Gallyas silver dyeing,four immunohistochemical methods were carried out The loss of neurons cells of all lobes of cerebral cortex,cingulate gyrus,amygdaloid nucleus,hippocampal gyrus,parahippocampal gyrus,meynert basal nucleus,substantia nigra,locus ceruleus,dorsal nucleus of vagus nerve,senile plaques (SP) and the changes of neurofibrillary tangles (NFT) were observed in detail The control study of pathology and imaging was carried out by comparison of CT in different phases before and after death of the patient.Results The degeneration of temporal lobe was marked: (1) The degeneration of middle frontal gyrus of cortex of frontal lobe was the most evident; (2) The degeneration of long gyrus was more evident than that of the short gyrus as the cortex of insular lobe was concerned; (3) The degeneration posterior part of cingulated gyrus was more evident than that of the anterior part.Conclusion The pathological findings of SDAT mentioned above are basically in conformity with the changes of imaging.