甲状腺乳头状癌与桥本甲状腺炎关系的免疫组化研究 |
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引用本文: | WAN Yizeng,杨京京,HE lifu,李敬岩.甲状腺乳头状癌与桥本甲状腺炎关系的免疫组化研究[J].中国现代医生,2008,46(14):9-10. |
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作者姓名: | WAN Yizeng 杨京京 HE lifu 李敬岩 |
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作者单位: | 辽宁医学院附属第三医院病理科,辽宁锦州,121001 |
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摘 要: | 目的探讨甲状腺癌与桥本甲状腺炎的关系。方法对27例甲状腺乳头状癌(7例合并桥本甲状腺炎)应用S—P法检测甲状腺癌细胞与HT中增生滤泡上皮中P53、C-erbB-2及PCNA的表达情况。结果癌细胞P53阳性23例(85.19%),C-erbB-2阳性21例(77.78%),PCNA高表达26例(96.3%)。HT增生滤泡上皮P53阳性5例(71.43%),C-erbB-2阳性4例(57.14%),PCNA高表达7例(100%)。结论HT中滤泡上皮增生属于异型增生,与癌细胞有一定的相关性,可视为癌前病变。
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关 键 词: | 甲状腺癌 乳头状癌 桥本甲状腺炎 关系 免疫组织化学 |
The Immunohistochemical Study on the Relationship of Thyriod Papillary Cacinoma and Hashimoto's Thyroiditis |
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Authors: | WAN Yizeng YANG Jingjing HE lifu LI Jingyan |
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Institution: | (Department of Pathology,The Third Hospital Affiliated to Liaoning Medical University, Liaoning 121001) |
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Abstract: | Objective To study the relationship of thyroid cacinoma and Hoshimoto' s thyroiditis. Methods By using immunohistochemical methods,the expression of P53,C-erbB-2 and PCNA in 27 cases of thyroid cancer and 7 cases of HT was studied. Results In tumor cells of thyroid cacinoma, 23 cases(85.19%) were positive of P53, 21 cases(77.78%) were positive of C-erbB-2 and 26 cases(96.3%) were high expression of PCNA. In hyperplastic follicle cells of HT, 5 cases(71.43%) were positive of P53, 4 cases(57.14%) were positive of C-erbB-2 and 7 cases(100%) were high expression of PCNA. Conclusion The proliferation of follicle cells in HT is hyperplasia, is related to tumor cells and can be regarded as precancerous lesions. |
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Keywords: | Thyroid cacinoma Papillary carcinoma Hoshimoto's thyroiditis Relation Immunohistochemistry |
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