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Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse |
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| Authors: | Thomas Wobrock Alkomiet Hasan Berend Malchow Claus Wolff-Menzler Birgit Guse Nicolas Lang Thomas Schneider-Axmann Ullrich K H Ecker Peter Falkai |
| Institution: | 1. Department of Psychiatry and Psychotherapy, Georg-August-University G?ttingen, Von-Siebold-Strasse 5, 37075, G?ttingen, Germany 2. Department of Neurology, Christian-Albrechts-University Kiel, 24195, Kiel, Germany 3. School of Psychology, University of Western Australia, Crawley, WA, 6009, Australia |
| Abstract: | Rationale/objectivesThere is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor cortex (M1) excitability in SZ. Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking. |
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