| 骨髓源性干细胞的异质性及在肠道修复中的作用研究进展 |
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| 引用本文： | 刘登群,粟永萍. 骨髓源性干细胞的异质性及在肠道修复中的作用研究进展[J]. 中国修复重建外科杂志, 2008, 22(9): 1130-1134 |
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| 作者姓名： | 刘登群 粟永萍 |
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| 作者单位： | 第三军医大学军事预防医学院防原教研室全军复合伤研究所创伤、烧伤与复合伤国家重点实验室,重庆,400038 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金 |
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| 摘 要： | 目的 对骨髓源性干细胞(bone marrow derived stem cells,BMDSCs)的异质性及其形成机制和意义进行综述,分析其在肠上皮重建中的作用和可能机制.方法 查阅和分析近年有关BMDSCs异质性和其在肠上皮损伤修复中作用的相关文献,并作进一步综合分析.结果 BMDSCs异质性可以解释其多向分化能力,可能以直接定植于肠道或通过和肠道干细胞融合以及促进损伤微环境的重建等多种机制参与肠上皮功能修复.结论 BMDSCs在炎症性肠病等胃肠道损伤和修复中具有广阔的应用前景.
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| 关 键 词： | 骨髓源性干细胞 异质性 肠上皮 上皮下肌成纤维细胞 炎症性肠病 |
RESEARCH ADVANCEMENT OF BONE MARROW DERIVED STEM CELL HETEROGENEITY AND ITS ROLE IN INTESTINAL EPITHELIAL REPAIR |
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| LIU Dengqun,SU Yongping. RESEARCH ADVANCEMENT OF BONE MARROW DERIVED STEM CELL HETEROGENEITY AND ITS ROLE IN INTESTINAL EPITHELIAL REPAIR[J]. Chinese journal of reparative and reconstructive surgery, 2008, 22(9): 1130-1134 |
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| Authors: | LIU Dengqun SU Yongping |
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| Affiliation: | College of Preventive Medicine, Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, 400038, P.R. China. |
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| Abstract: | OBJECTIVE: To summarize and review the heterogeneity of bone marrow derived stem cells (BMDSCs) and its formation mechanism and significance, and to analyze the possible roles and mechanisms in intestinal epithelial reconstruction. METHODS: The related literature about BMDSCs heterogeneity and its role in intestinal epithelial repair was reviewed and analyzed. RESULTS: The heterogeneity of BMDSCs provided better explanations for its multi-potency. The probable mechanisms of BMDSCs to repair intestinal epithelium included direct implantation into intestinal epithelium, fusion between BMDSCs and intestinal stem cells, and promotion of injury microcirculation reconstruction. CONCLUSION: BMDSCs have a bright future in gastrointestinal injury caused by inflammatory bowl disease and regeneration. |
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